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Open clinical trials and recently completed clinical trial results

Congratulations to Dr Argyrios Stampas and his team on his recent successful grant!

Improving accessibility to Urodynamic Studies through education and training of SCI providers

  • Funder: Craig H Neilsen Foundation, 2025
  • Total amount over 2 years: $195,500
  • Collaborators: Blayne Welk, Michael Kennelly, John Stoffel, Rose Khavari

Grant summary
Urodynamic studies (UDS) are one of the most important aspects of the clinical care of neurogenic bladder (NB) in people with spinal cord injury (SCI). This test provides essential information about the risk of renal failure and urinary infections from neurologic changes in the bladder, and is essential to address important quality of life issues like urinary incontinence. Every person with SCI should have a UDS performed, however there are accessibility barriers that prevent this from occurring, including clinicians that cannot accommodate people with SCI and limited knowledge in performing or interpreting UDS in SCI. The main goal is to improve access to UDS for people with SCI. We will do this by creating online training and education materials to help encourage providers to perform UDS in SCI, based on consensus recommendation and international guidelines. This will be a multidisciplinary undertaking of stakeholders involved with UDS in SCI: neuro-urologists, nurses, medical assistants, technicians, SCI clinicians, and people with SCI lived experience (PLEX).

Article

Accuracy of Urinary Symptoms Questionnaires for People with Neurogenic Bladder who can Void or who use Catheters

Veiw PDF File

Article

How well Urinary Symptoms Questionnaires Work for People with Neurogenic Bladder who can Void or using Indwelling Catheters

Veiw PDF File

Probiotic Lactobacillus is safe and well tolerated when instilled in the bladder

Veiw PDF File

  • There are bacteria that reside in urine and healthy bladders (this is termed the healthy urobiome).
  • Lactobacillus is a type of bacteria that is considered to be a “probiotic” or beneficial to health.
  • People with neurogenic lower urinary tract dysfunction (NLUTD) (neurogenic bladder) have less or even no probiotic Lactobacillus in their bladders and this may contribute to urinary symptoms and urinary tract infection.
  • This study evaluated the safety and tolerability of instilling a probiotic, Lactobacillus rhamnosus GG (LGG), directly into the bladder using the bladder catheter in individuals with neurogenic bladder.
  • When participants experienced cloudy or more foul-smelling urine, they mixed LGG with normal saline and instilled the mixture into the bladder using their bladder catheter.
  • Doing this was found to be safe and well-tolerated.

Ongoing clinical trial investigating the effects of transcranial magnetic stimulation (rTMS) on bladder function in individuals with multiple sclerosis.

Veiw Trial

Research Project 1

Intravesical Probiotic (Lactobacillus) for Urinary Symptoms Among People with Neurogenic Lower Urinary Tract Dysfunction Who Use Indwelling Catheters

The objectives of this study are to:

  1. Describe the bacteria normally present in healthy urine; and
  2. Estimate the effect of intravesical Lactobacillus GG probiotic dose on urinary symptoms

Participants must be:

  • Be diagnosed with neurogenic bladder (SCI, MS, SB, Stroke etc.);
  • Use indwelling catheterization for bladder management
  • Be 18 years or older;
  • Have a history of 2 or more episodes of urinary symptoms in the past year.

If you are interested in participating, please submit the survey:

* Required feilds

Virtual Neurogenic Bladder Care Companion

Funded by the Craig H Neilsen Foundation

Dr Iryna Crescenze The Ohio State University Wexner Medical Center, Columbus, OH

The purpose of this project is to create a virtual care companion linked to the medical record and integrated directly into the urology care for patients with spinal cord injury (SCI) and neurogenic bladder. The Neurogenic Bladder Care Companion (NGB Care Companion) will provide interactive education about living with a neurogenic bladder, managing complications, and optimizing quality of life. It will be available through the smart phone application, myChart ®, powered by Epic Systems © electronic medical record software. The platform will allow for bidirectional flow of information between patients and clinicians and help guide medical care and decision making during medical visits. This project will empower individuals with SCI to be engaged in their bladder health and promote independence. It will also help remove physical and social barriers to early urologic care by providing completely virtual access to succinct, evidence-based information and bladder tracking tools.

Ongoing Clinical Trials

Dr Argy Stampas

A Randomized Controlled Trial of Transcutaneous Tibial Nerve Stimulation for Neurogenic Lower Urinary Tract Dysfunction. Funded by NIDILRR and the Craig Neilsen Foundation.

Can Urine Biomarkers Characterize the Developing Neurogenic Bladder in Acute Spinal Cord Injury? A pilot trial.

Developing online calculator for prognosis of spontaneous voiding after early SCI. An NBRG, Praxis, and European Model Systems collaboration.